Pentraxin-3 – a promising biological marker in heart failure: literature review
نویسندگان
چکیده
According to many studies, inflammation plays a very significant role in the pathogenesis of heart failure. Many studies have demonstrated an increase circulating levels inflammatory markers and cytokines such as C-reactive protein, tumor necrosis factor-a (TNF-a), interleukins. protein is produced liver response stimulation by various cytokines, mainly interleukin-6, member pentraxin superfamily. Pentraxin-3, which long pentraxin, has C-terminal domain similar classic short pentraxins, but differs from them presence unrelated N-terminal domain. Various cell types can produce pentraxin-3 when exposed primary signals interleukin-1, oxidized low density lipoprotein, microbial fragments (eg, lipopolysaccharide, lipoarabinomannans). Data experimental animal models that play cardioprotective atheroprotective roles through its influence on process. Pentraxin-3 been studied several clinical protocols potential biomarker for cardiovascular disease.
منابع مشابه
Pentraxin 3 as a Novel Marker Predicting Congestive Heart Failure in Subjects With Acute Coronary Syndrome
BACKGROUND AND OBJECTIVES Pentraxin 3 (PTX3) was shown to be elevated in the acute phase of acute myocardial infarction (AMI) and to have prognostic significance in AMI patients. The aim of this study was to estimate whether the value of PTX3 could be used as a prognostic biomarker, with the global registry of acute coronary events (GRACE) risk assessment tool, in patients with acute coronary s...
متن کاملPentraxin 3, a new marker for vascular inflammation, predicts adverse clinical outcomes in patients with heart failure.
BACKGROUND Pentraxin 3 (PTX3) is a novel inflammatory marker produced by endothelial cells, smooth muscle cells, and macrophages. The purpose of the present study was to examine the clinical significance of plasma PTX3 levels in patients with heart failure. METHODS We measured the plasma PTX3 levels in 196 patients with heart failure and 60 control subjects without heart failure by sandwich e...
متن کاملPentraxin 3 is a new inflammatory marker correlated with left ventricular diastolic dysfunction and heart failure with normal ejection fraction.
OBJECTIVES This study investigated the clinical significance of plasma pentraxin 3 (PTX3) levels in patients with heart failure with normal ejection fraction (HFNEF) and whether PTX3 is produced from coronary circulation. BACKGROUND Pentraxin 3 is a novel inflammatory marker and a member of pentraxin superfamily including C-reactive protein (CRP). The relationship between inflammatory markers...
متن کاملPentraxin 3 as a Novel Marker in Cardiovascular Diseases?
Pentraxin 3 (also known as TNFAIP5, TSG-14) belongs to the superfamily of proteins characterized by cyclic multimeric structure. Pentraxin 3 (PTX3) is synthesized locally at the inflammatory sites by endothelial and smooth muscle cells upon exposure to inflammatory signals such as IL-1β, TNF-α or ox-LDL, but not IL-6. Furthermore, PTX3 is highly expressed in vascular cells and myocardial cells ...
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ژورنال
عنوان ژورنال: Consilium medicum
سال: 2022
ISSN: ['2075-1753', '2542-2170']
DOI: https://doi.org/10.26442/20751753.2022.1.201382